The Most Common Five Classes Of Analgesics To Cure Your Pain
Analgesics, mostly known as painkillers, are medicines used to relieve pain. Analgesic medicines provide relief from pain, bringing no change in your neural and conscious activities or putting you to sleep.
These medications can numb different types of pain, ranging from headaches to arthritis and minor to moderate injuries.
Experts have put all those analgesics together that have similar pain-relieving properties or work similarly. One of the most common groups is NSAIDs (nonsteroidal anti-inflammatory drugs).
Anyway, here are five more, and all different target kinds of pain. Some pain relievers can be bought without prescriptions, while others require them.
- NSAIDs are used to treat minor to moderate pain, inflammation, and fever.
- Opioid analgesics are the most potent painkillers, often used for severe pain relief.
- Salicylates, like aspirin, help reduce pain and inflammation and prevent blood clotting.
- Cox-2 inhibitors target pain and inflammation while minimizing stomach ulcer risks.
- Miscellaneous analgesics, such as acetaminophen, are commonly used for fever and mild pain.
- Opioids can lead to side effects such as constipation, dizziness, and respiratory depression.
- Acetaminophen should be taken in moderation to avoid liver toxicity and other complications.
This article explains all five types of analgesics, their uses, their drugs, their side effects, and their considerations.
When Can You Use Analgesics?
Analgesics are used:
- After surgery
- In cancer treatment
- To relieve headaches
- For chronic pain such as arthritis or lower back pain
- For injury
What Are The Types Of Analgesics?
Analgesics kill pain, or discomfort related to disease, injury, or surgery. Not all pains are similar, so to deal with them, multiple types of analgesics work to provide relief by following different drug classifications.
Here are five different classes of analgesics:
1. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
NSAIDs work against those substances that cause inflammation, discomfort, pain, and fever.
List of mainly used NSAID Drugs
Ibuprofen (Motrin)
This is available OTC without a prescription. It is a flu analgesic that can treat mild-to-moderate pain, fever, body aches, and the common cold. It is also believed to be the best analgesic for toothache
Naproxen (Naprosyn)
It is used to treat Arthritis. However, it can also treat mild pain like headaches, backache, fever, and muscle pain.
Ketorolac (Toradol)
It is suggested after surgery to relieve moderately severe pain and inflammation.
Nabumetone (Relafen)
It treats the pain, stiffness, and inflammation experienced in osteoarthritis and rheumatoid arthritis.
Diclofenac (Voltaren)
It treats mild-to-moderate pain, muscle pain, and inflammation in arthritis. It is also prescribed after dental surgeries to lessen the pain.
Indomethacin (Indocin)
It is used to decrease the pain and swelling in arthritis, gout, bursitis, and tendonitis.
For what conditions are NSAIDs used?
NSAIDs treat minor to moderate pain, inflammation, and fever. Most NSAIDs work by producing prostaglandins — the chemicals that sensitize the nerve endings.
NSAIDs are used to treat mild-moderate headaches, menstrual pain, seasonal cold & flu, arthritis, and muscle sprains & strains.
What are some common side effects of NSAIDs?
Almost all NSAIDs risk stomach ulcer, indigestion, gastrointestinal bleeding, N/V/D, dizziness, and drowsiness.
What to consider before taking NSAIDs?
- It is better to avoid NSAID drugs if you’re dealing with any peptic ulcer disease, gastritis, or renal or hepatic insufficiency.
- If you’re taking Ibuprofen regularly, it can increase lithium toxicity.
2. Opioid Analgesics
Analgesic opioids, also known as narcotics, change the brain’s perception of pain. These are some of the most potent pain-killing medications.
List of common Opioid Analgesic drugs
Oxycodone (OxyContin)
It treats severe pain with opioid tolerance. This drug helps in moderate-to-severe pain.
Oxymorphone (Opana)
It is used when the pain is decreased by other medications.
Hydrocodone (Zohydro)
It is prescribed to patients to treat severe pain for a long time. It is used in combination with additional drugs.
Hydromorphone (Dilaudid)
These treat ongoing severe pain. When no other pain medications work, Hydromorphone is prescribed.
Morphine (MS -Contin)
This drug treats severe pain for extended periods. It makes the patient drowsy.
Fentanyl or Methadone (Dolophine)
It is used to ease the withdrawal symptoms in addicts. It helps to quit heroin.
Tramadol (Ultram)
It helps treat moderately severe pain, typically after surgery. It is also prescribed to treat ongoing pain.
Codeine Meperidine (Demerol)
It is prescribed for severe pain. It can make the patient dizzy.
For what conditions are Opioids used?
Opioids are commonly used for moderate to severe pain. The pain can be acute and chronic as well. Other than that, opioids are used to lessen pain from bone fractures, tooth extractions, and surgery.
What are some common side effects of Opioids?
Opioid analgesics can cause dizziness, nausea, and vomiting. The user is also prone to constipation and respiratory depression. All these side effects most of the time to resolve after continued use. However, opioids can also lead to addiction.
Less common side effects of opioids include seizures, hallucinations, lower blood pressure, itching, impaired thinking, and urinary retention.
What to consider before taking Opioids?
- Drugs like barbiturates, phenothiazine, and MAOIs can increase the risk of respiratory depression, hypotension, and sedation.
- If you are a patient with coronary artery disease (CAD), myocardial infarction (MI), or hypertension, it is best to avoid opioids.
- If you have been using opioids for an extended period, do not stop abruptly. There can be severe withdrawal problems.
3. Salicylates
Salicylates are analgesics that are naturally present in plants and also derived from salicylic acid. Only a few salicylates can work to relieve pain by working similarly to NSAIDs.
List of common Salicylate drugs
Aspirin
It helps in reducing fever, mild-to-moderate pain, body aches, and inflammation.
Diflunisal
It is prescribed to treat mild pain. It can also help with inflammation and muscle stiffness in less severe cases of arthritis.
Magnesium salicylate
It is prescribed to relieve pain and inflammation in arthritis.
For what conditions are Salicylates used?
Salicylates are not only pain-relievers but are also used as food preservatives and antiseptics.
Drugs like aspirin treat moderate pain, inflammation, headaches, cold & flu, toothaches, arthritis, and blood clotting.
What are some common side effects of Salicylates?
Salicylates do work to give you relief from pain. But you can feel nausea or vomit after using it. Mild headaches and drowsiness are also one of their after-effects. GI bleeding or stomach pain is less common but can be severe side effects of using salicylates.
What to consider before taking Salicylates?
- Avoid salicylates if you are using other anticoagulants.
- If you’ve taken an overdose of salicylates, activated charcoal can help in reducing its effectiveness.
4. Cox-2 Inhibitors
Cox-2 inhibitors are from the NSAIDs group and work to block COX-2 enzymes. COX-2 enzymes release prostaglandins after any injury or infection. They reduce the risk of GI ulceration and bleeding.
List of common Cox-2 inhibitors drugs
Celecoxib (Celebrex)
Celecoxib is an analgesic used for relieving pain and inflammation in osteoarthritis. Moreover, it is also prescribed to treat mild to moderate pain and migraines.
For what conditions are Cox-2 inhibitors used?
Cox-2 inhibitors control moderate pain and inflammation. This drug is also used for rheumatoid arthritis and ankylosing spondylitis.
What are the side effects of using Cox-2 inhibitors?
No drug comes without side effects, mainly if you use them more than once, and cox-2 inhibitors are no different.
Gas and bloating can be early side effects. You can also face the problem of sore throat and cold. Dizziness, constipation, and a less effective sense of taste are the most common after-effects of this analgesic formula.
What do you need to consider before using Cox-2 inhibitors?
- A cox-2 inhibitor can cause stomach ulcers, leading to bleeding and holes in the intestines and stomach.
- It is also advised not to use CABG (coronary artery bypass graft ) surgery in patients.
Miscellaneous Analgesics
Miscellaneous analgesics are considered unique as they work to tame the COX enzyme, but not like how NSAIDs do.
Common Miscellaneous Analgesics drug
Acetaminophen (Tylenol)
It treats pain in periods, sore throats, body aches, toothaches, and backaches. It can also treat fever.
For what conditions are Miscellaneous Analgesics used?
Miscellaneous analgesic drugs are used for fever and moderate pain. The pain can be a headache, muscle or joint strain, cold, fever, toothache, and menstrual pain.
What are some common side effects of taking Miscellaneous Analgesics?
You can feel nausea and mild pain in the stomach. Itching and rash can also occur. Clay-colored stools and dark urine are also the common side effects of using miscellaneous pain relievers.
What to consider before taking Miscellaneous Analgesics?
- Miscellaneous analgesic drugs can cause liver toxicity.
- Use as per advice. It is said that the limit is 3-4 grams in the span of 24hr.
- Using this can alter the reading of blood glucose.
Takeaway
While you can find analgesics in your local drugstore, you might have difficulty finding them with precise dosing instructions. Several types of analgesics vary in the amount of relief they provide, the length of comfort they provide, and the pain they treat. “Analgesics” refers to any medication used to relieve pain.
They can be divided into five categories: nonsteroidal anti-inflammatory drugs (NSAIDs), opioid analgesics, COX-2 inhibitors, and muscle relaxants. They have a limited number of side effects and work quickly, but they can also lead to stomach and GI problems.
Analgesics are primarily opioid-based and work by producing endogenous opioid peptides; however, they can also be mixed with other medications and are known as mixed agonists/antagonists.
They are the most potent pain relievers but can also lead to constipation, nausea, vomiting, and drowsiness. Muscle relaxants are the most common class of analgesic, and they target areas of your body that are tense or are associated with pain.
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