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Amenorrhea: A Disturbing Factor In A Woman’s Life 

  • Author by Raazi
  • Reviewed By Raazi
  • Last Edited : December 12, 2024
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Women usually feel very uncomfortable and helpless while talking about periods. However, they don’t know that the reason behind enjoying health, beauty, activeness, sex, and many other things is the regular menstruation cycle. Many women believe that getting their period once a month is inconvenient, and for some, it can even cause painful symptoms such as mood swings, migraines, and stomach cramps. 

Many women share these symptoms. Even though it may feel liberating at the moment, a hormonal imbalance is most likely the cause of a few missed periods.

Here we will analyze the importance of menstruation to balance a woman’s hormones and discuss why menstruation may indicate a health condition. 

This article investigates amenorrhea, sometimes known as a lack of menstrual cycles, and its causes, symptoms, and potential therapies.

  • Amenorrhea can increase the risk of cardiovascular issues due to low estrogen levels.
  • Women with primary amenorrhea often have a higher likelihood of underlying genetic syndromes.
  • Long-term untreated amenorrhea can lead to infertility and chronic health conditions.
  • Secondary amenorrhea is a leading symptom in athletes with “female athlete triad syndrome.”
  • Vitamin D and calcium deficiencies may exacerbate amenorrhea-related bone loss.
  • Psychological stress can intensify amenorrhea by disrupting the hypothalamic-pituitary-gonadal axis.
  • Biofeedback and mindfulness techniques can help manage stress-induced amenorrhea.

A Hormone Examination Throughout A Menstrual Cycle

A woman’s body is susceptible to a complicated interaction of four essential female hormones during her monthly cycle: follicle-stimulating hormone, luteinizing hormone, estrogen, and progesterone.

 This contact influences whether a woman becomes pregnant.

These hormones’ normal rise and fall during a woman’s menstrual cycle makes her more fertile and ready to conceive. If fertilization does not occur, the woman’s menstrual cycle will begin again. The absence or absence of menstruation shows that this finely tuned hormone network isn’t working properly. 

It’s a sign that something is wrong when you’re not pregnant or in the perimenopausal period.

Amenorrhea Definition

The medical word for the absence of menstruation in women of reproductive age is amenorrhea. The absence of bleeding in menstrual conditions due to some health or physical imbalances between puberty and menopause shows your underlying health problem, such as hormonal imbalance. 

Amenorrhea can be diagnosed when three or more menstrual cycles have not occurred.

Types Of Amenorrhea

Amenorrhea can happen for several causes. As previously said, it is defined as skipping three or more periods in a sequence instead of skipping one period here and there. 

Amenorrhea can be classified into two types.

The Primary Amenorrhea

Primary amenorrhea is the medical word for the condition that happens when a woman reaches the age of 15 without having had her first menstruation.

Secondary Amenorrhea

Secondary amenorrhea is the medical term for a woman of reproductive age who once had started her menstruation suddenly stops getting her periods due to some medical issue.

The Commonly Occurring Causes Of Primary Amenorrhea

Some of the potential reasons a girl could not get her first period by the age of 16 are:

Chromosomal or Genetic Abnormalities

Due to genetic abnormalities, ovaries stop functioning as they should in females. In some young females, the X chromosome is partially absent or sometimes completely, resulting in ovarian dysfunction. The release of an egg from the ovaries is governed by how well the ovaries operate, which affects the release of estrogen and progesterone (ovulation). 

Because estrogen is so crucial in a woman’s biology, this will have a major impact on her health and well-being, including her capacity to conceive children. 

Another reason is categorized by the presence of high testosterone hormone levels, which delays or disrupts the process.

Complications With The Hypothalamus Or The Pituitary Gland

This medical condition is hypothalamic amenorrhea. The hypothalamus in the brain assists the pituitary gland in secreting hormones into the bloodstream. Problems with either of these might cause a hormonal imbalance, which delays the monthly menstruation cycle. 

Usually, external factors like high physical exertion, extreme stress, and bad eating habits are responsible for this disorder.

Issues with the Sexual and Reproductive System

This refers to a condition where the reproductive organs either do not exist or have not grown fully in the body.

The Implications of Secondary Amenorrhea

Naturally Occurring Causes

Secondary amenorrhea sometimes occurs for various natural causes, including pregnancy, breastfeeding, and the menopausal transition. Hormonal contraception can also cause a lack of menstruation. After discontinuing hormonal birth control, some women develop amenorrhea, and their hormone levels gradually return to normal over two to four weeks. 

This is a common occurrence. If a woman’s period does not return after three months of stopping hormonal birth control, she should see her healthcare physician.

Antidepressants and Blood Pressure Medicines

Antidepressants and blood pressure medications may increase hormone levels that inhibit ovulation and the menstrual cycle.

Chemotherapy and Radiation

Chemotherapy and radiation done for curing hematologic cancer (bone marrow, blood, and lymph nodes) and gynecologic or breast cancer can harm estrogen-producing cells and eggs in the ovaries, causing amenorrhea. 

Particularly in younger women, the subsequent amenorrhea may be brief.

Scar Tissue

Scar tissue can sometimes form in the uterine lining, hindering the menstrual cycle’s regular removal of the uterine lining. 

This scarring may develop during a dilation and curettage (D&C) procedure, in which tissue is removed from the uterus to identify or treat heavy bleeding or to clean the uterine lining after a miscarriage, a cesarean delivery, or treatment for uterine fibroids.

Amenorrhea Caused by Malfunctioning of the Hypothalamus

The hypothalamus, a part of the brain that regulates body activities, decreases or terminates the production of gonadotropin-releasing hormone (GnRH), the hormone that triggers menstruation. 

The following traits are present in women with hypothalamic amenorrhea. 

  • Emotional stress
  • High-intensity exercise burns more calories than you ingest.
  • Reduced body weight
  • Low amount of body fat
  • Consuming very few calories or fat
  • A deficit in leptin, a protein hormone that influences appetite and metabolism
  • Certain medical conditions or diseases

Gynaecological Disorders

Secondary amenorrhea is a typical sign, especially those resulting from or causing hormonal imbalances.

Polycystic ovarian syndrome

When a woman’s body produces an unusually high number of androgens, PCOS develops (a kind of hormone). 

Egg release may be impeded by the formation of fluid-filled sacs or cysts in the ovaries when testosterone levels are elevated (ovulation)—the majority of women with PCOS experience amenorrhea or oligomenorrhea, or irregular periods.

Fragile X syndrome-related primary ovarian insufficiency (FXPOI)

FXPOI refers to a condition in which a woman’s ovaries stop functioning before the usual menopause, which can occur as early as age 40. Mutations in an X-chromosome gene cause FXPOI. 

FXPOI is common among women seeking amenorrhea treatment.

Thyroid Problems

The thyroid gland is a small butterfly-shaped gland found right under Adam’s apple at the base of the neck. Hormones produced by the thyroid gland regulate metabolism and are implicated in puberty and menstruation. 

Menstrual irregularities, including amenorrhea, may be caused by a hyperactive or hypoactive thyroid gland (hypothyroidism).

Pituitary Gland Malignancies

The pituitary gland in the brain regulates hormone synthesis, which impacts various physiological processes, such as the reproductive cycle and metabolism. Tumors of the pituitary gland are typically benign; however, they may interfere with the body’s hormonal management of menstruation.

Lifestyle-Related Disorders

After you’ve checked out all other options, it’s time to focus on your lifestyle and start looking for associated problems. The way you live your life can have a significant impact on the state of your hormones. 

Various factors can cause hormonal imbalances, including but not limited to work or family-related stress, insufficient or excessive sleep, poor nutrition, too much or too little exercise, and being under or overweight.

Disturbance in the biological clock

Our body works with the natural clock. The day is for work and the night for sleep; all work is distributed according to the clock.

This clock is also in charge of regulating our bodies’ and hormones’ cycles: Our sleep-wake cycle, as well as other hormones like FSH, LH, and growth hormones, are all finely tuned to this clock. All these factors are vital in reproductive system maturation and the onset of menstruation.

A healthy lifestyle that includes all the workings of life without touching the dangerous limit of disturbance benefits the body’s mechanism and your hormone network. 

Being overworked, not eating enough to fuel your activities (including unexpected activities like cleaning or playing with the kids), and not getting enough rest on time, can all be factors that cause your body’s normal cycles and hormone network to become disorganized.

Restless Sleep

Under the 24-hour cycle rhythm, your body generates hormones such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Restless or insufficient sleep results in low levels of these two regulatory hormones affecting the hormones produced by the ovary.

Menstrual periods will become unpredictable because of disturbances in estrogen and progesterone, and sometimes, will halt totally.

Poor Diet

If you don’t eat enough or the right kind of food, your body will start looking for energy sources that it may receive from other places. Menstruation is a non-essential biological function of the body. It can stop happening in extreme situations such as over-exercising and under-fueling and in those suffering from eating disorders such as anorexia.

Secondary amenorrhea is a prevalent problem among female athletes, and the medical world refers to it as REDS (Relative Energy Deficiency in Sport). 

This syndrome is caused by excessive workouts and poor nutrition (RED-S). 

RED-S, on the other hand, is not only seen in female athletes; it also has the potential to affect women who do not consume enough calories to sustain their level of physical activity.

The Symptoms Of Amenorrhea

The problem’s underlying cause must first be identified to treat amenorrhea symptoms properly. Acne, quick weight gain or loss, sadness, and rapid weight gain or loss are all signs of polycystic ovarian syndrome and increased facial hair. 

Hypothyroidism can be present in various ways, including fatigue, cold sensitivity, constipation, sluggish movement and cognition, muscular weakness, and pains.

All of these symptoms, as well as the ones listed below, are caused by a hormonal imbalance.

  • Vision growing fuzzy or blurred
  • Stress and depression
  • Gastrointestinal distress, constipation, or diarrhea 
  • Excessive hair growth (hirsutism) on the face and chest, like men
  • Fertility issues or issues regarding reproduction
  •  A decrease in hair volume 
  • Difficulty concentrating and issues related to memory
  • Skin becomes either overly dry or too greasy or both 
  • An increase in thirst as a result of increased urination.
  • Sweating off and on
  • Unreasoning increase or decrease in weight
  • Anxiety and panic caused by irregular heartbeats or palpitations
  • Decreased sexual desire
  • sensitivity to hot or cold surroundings
  • Muscle fatigue can appear in various ways, including pins and needles, weak muscles, and cramping.
  • Heartbeat at a slow rate

Treating The Secondary Amenorrhea

The secondary amenorrhea treatment depends on the symptoms and conditions you are facing. If you experience secondary amenorrhea resulting from lifestyle variation, then modifying some components of your lifestyle will help. 

These changes will rebalance your hormone network, and there are greater chances that your periods will resume.

However, if it is determined that a medical issue is to blame, medications that restore hormone balance may be recommended.

Restoration Of Menstruation Cycle From Amenorrhea

After a period of not having periods (amenorrhea), having periods again is a sign that your hormone levels are properly fluctuating. It can be very encouraging and full of apprehensions for a woman who has been going without periods. The first and further two or three periods will let you believe that she is coming on track now.

Monitoring your hormone levels is the best approach to determining how quickly your body recovers once you resume menstruation. If you are in good health, you can safely assume your life has returned to normal, just like others. 

If amenorrhea was caused by poor nutrition and over-exertion, you might try to resume soon after recovery. However, it would help if you waited for some time or considered yourself overburdened.

Takeaway

Primary amenorrhea is not very common among young girls, but secondary amenorrhea is frequently found that indicates a disrupted hormonal network. Monitoring your FSH, LH, estrogen, and progesterone levels during a menstrual cycle might provide insight into overall hormonal health. 

This will show whether your hormones are rising and falling at the appropriate times during your menstrual cycle. 

It is vital to evaluate amenorrhea clinically as soon as possible to identify the underlying cause of the condition. Inadequate nutrition, hormonal imbalances, diseases, and certain medicines can all contribute to the emergence of this disorder. If you want to watch for any problems that affect your hormone network, you should be aware of how your hormone levels change throughout your menstrual cycle. 

Amenorrhea: A Disturbing Factor In A Woman’s Life 

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