Glucosamine is a naturally occurring chemical present in cartilage. Cartilage is a hard tissue that protects joints. The body uses glucosamine to create other compounds that help to develop tendons, ligaments, cartilage, and the mucus that protects joints.

Chemically, it is a complex carbohydrate. It is primarily present in the body in three forms: 

• Glucosamine sulfate
• Hydrochloride
• N-acetylglucosamine

Glucosamine supplements are produced from shellfish, with the most used glucosamine sulfate. These joint health supplements are easily available at pharmacies. 

• It is helpful for joint health because cartilage deteriorates and becomes thinner as we age. There is evidence that Glucosamine slows this process down. Sulfur is incorporated into the structure to aid in cartilage growth and repair. 
• The benefits of this supplement are sufficient for those with hip or knee arthritis. 
• Supplements containing glucosamine and chondroitin may also help reduce chronic inflammation. We know inflammation is a cause of several potential health concerns, including cardiovascular disease, sugar, and arthritis. Perhaps it is another cause why Glucosamine eases arthritis pain.
• Glucosamine appears to alleviate joint discomfort in persons with osteoarthritis.
• Supplements containing glucosamine and chondroitin, a similar molecule found in cartilage, have been showed to be as beneficial as osteoarthritis drugs like celecoxib (Celebrex). 
• This supplement is a safe alternative for individuals who cannot adapt very well to NSAID and anti-inflammatory drugs. It aids in alleviating arthritis symptoms.

• Its advantages resemble those of Glucosamine to some extent. To minimize excessive friction between bones, this supplement aids cartilage in retaining water.
• It slows the development of osteoarthritis.
• Chondroitin enhances the collagen protein’s capacity to absorb stress, whether used alone or in combination with other supplements. Chondroitin sulfate instructs the immune system to increase collagen production to stop cartilage destruction.
• It stops an enzyme from breaking down cartilage. 
• Hyaluronic acid is a different supplement. It is combined to create a spring-like molecule. As a result, the cartilage’s flexibility and strength are improved. 
• People with hand arthritis benefit particularly from Chondroitin. Even if it doesn’t increase grip strength or lessen the need for painkillers, it nonetheless helps these people with morning stiffness.

• Proteoglycan, a component of cartilage, isn’t formed in adequate quantities in osteoarthritis. To stop the breakdown of proteoglycan, SAM-E improves how these enzymes function.
• SAM-E helps to loosen up tight joints. As a result, mobility is enhanced. 
• It has been seen to be highly beneficial in reversing the extreme tiredness and physical discomfort linked to fibromyalgia. 
• SAM-E can also treat tendonitis, an inflammation of the body’s tendons. An inflamed bursa is a fluid-filled cushioning sac located between tendons and bones. Joint discomfort and bursa swelling result from this.
• SAM-E is especially beneficial for lowering pain and edema.
• This supplement can also help those with persistent lower back discomfort from excess weight or sports injuries.

Chili peppers contain a compound called capsaicin. The way these supplements for healthy joints reduce pain by influencing nerve cells is fascinating. It’s used topically as a cream or patch. It induces the activation of specific nerve receptors that are responsible for the stinging or itching sensation.

• Long-lasting receptor activation is achieved by capsaicin. 
• Over-reception eventually causes the receptors’ capacity to operate to be lost. As a result, these receptors likewise cease to process pain-inducing impulses. 
• By overusing the receptors, this supplement, when used frequently, helps dull the feeling of pain.
• Capsaicin helps reduce pain brought on by osteoarthritis, fibromyalgia, and rheumatoid arthritis. 
• After just one month of use, it contributes to a 50% reduction in pain. 
• It aids in easing pain brought on by nerve damage brought on by HIV or diabetic neuropathy.

Turmeric contains a chemical known as curcumin. Although turmeric is solely used to flavor food or add color to cosmetics, it also has advantages for the health of your joints. 

• Osteoarthritis and rheumatoid arthritis pain are both lessened by Curcumin. 
• Curcumin can also help lower swelling and inflammation in the area for smooth cushioning and increased mobility when the bursa expands and causes joint pain. 
• It inhibits the enzymes responsible for the body’s production of inflammatory mediators. The mediator COX-2, a target of many painkillers, is one of Curcumin’s targets. As a result, curcumin can replace NSAIDs. 
• This pill prevents further inflammation, as opposed to treating joint inflammation. 
• This supplement can help those with osteoarthritis of the knee. 
• Curcumin can sometimes be more beneficial than NSAIDS in treating rheumatoid arthritis.

Fish oils naturally include omega 3s, which have long been used for their health advantages. Pain alleviation is one of the critical advantages of omega 3s. DHA (docosahexaenoic acid) and EPA are the two crucial omega 3s for pain relief (eicosapentaenoic acid). They don’t repair joint injury or contribute to the production of new cartilage. Instead, their primary purpose is to relieve discomfort. When omega 3s are consumed as supplements, the body transforms them into resolvins. Compared to regular fatty acids, these molecules are 10,000 times more efficient. 

• They prevent the inflammatory immune system mediators from doing their jobs. 
• Our body is equipped with its own on/off switch for inflammation. Omega 3s prevent these switches’ activation, blocking the inflammatory process’s progression.
• The most effective treatment for rheumatoid arthritis discomfort has been omega-3 fatty acids. 

Synovial fluid, which is present between joints and facilitates easy bone sliding, contains hyaluronic acid. This part disintegrates in people with rheumatoid arthritis, which impairs the fluid’s ability to operate. While its primary method of pain relief is through injections, the same substance is also present in supplements at very tiny levels. 

• Low doses of this acid have been shown in research to relieve joint stiffness and chronic pain. 
• You can take hyaluronic acid 50mg pills twice daily with meals if you have knee osteoarthritis.
• Your doctor could suggest an injectable if your condition is more serious.